The present work represents the synthesis, characterization, and antimicrobial studies of novel series of 2,4-bis(hydrazino)-6-\nsubstituted-1,3,5-triazine and their Schiff base derivatives. IR, NMR (1H and 13C), elemental analysis, and LC-MS characterized the\nprepared compounds.The biological activity of the target products was evaluated as well. Twenty-two of the prepared compounds\nwere selected according to their solubility in aqueous DMSO. Only eight compounds showed good activity against the selected\npathogenic bacteria and did not show antagonistic effect against fungus Candida albicans. Two compounds 4k and 5g have widerange\neffect presently in Gram-positive and Gram-negative bacteria while other compounds (4f, 4i, 4m, 5d, 6i, and 6h) showed\nspecific effect against theGram-negative orGram-positive bacteria.The minimuminhibitory concentration (MIC,
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